2015–16 Mercyhurst Lakers women's ice hockey season

The Mercyhurst Lakers represented Mercyhurst University in CHA women's ice hockey during the 2015-16 NCAA Division I women's ice hockey season. The Lakers were the regular season champions of the College Hockey America Conference (CHA), as well as the CHA Tournament Champions. They were defeated in the NCAA Championship Tournament by #2 Wisconsin.

Offseason

 * August 7: Emily Janiga earned her second consecutive invitation to the USA Hockey Women's National Festival in Lake Placid, New York. The festival shall determine the roster of the Under-22 team that shall compete in a three-game series versus the Canadian U22/Development Squad from Aug. 19-23 in Lake Placid.

Schedule
!colspan=12 style=""| Regular Season

!colspan=12 style=""| CHA Tournament !colspan=12 style=""| NCAA Tournament

Awards and honors

 * Rachael Smith, CHA Rookie of the Year
 * Sarah McDonnell, CHA Goaltender Award
 * Mike Sisti CHA Coach of the Year
 * J'Nai Mahadeo, D, All-CHA Second Team
 * Rachael Smith, F, All-CHA Rookie Team
 * Molly Blasen, D, All-CHA Rookie Team
 * Sarah McDonnell, G, All-CHA Rookie Team